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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC6
All Species:
13.94
Human Site:
S1189
Identified Species:
25.56
UniProt:
Q03468
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03468
NP_000115.1
1493
168416
S1189
K
S
K
T
K
H
H
S
V
A
E
E
E
T
L
Chimpanzee
Pan troglodytes
XP_507781
1491
168031
S1187
K
S
K
T
K
H
H
S
V
A
E
E
E
T
L
Rhesus Macaque
Macaca mulatta
XP_001107536
1496
168876
S1192
K
S
K
T
K
H
H
S
V
A
E
E
E
T
L
Dog
Lupus familis
XP_534944
1486
168108
S1182
H
K
S
K
T
K
H
S
V
L
E
E
E
T
L
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
NP_001100766
1325
148468
T1042
R
L
S
A
V
A
S
T
S
E
K
Q
G
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508174
968
109820
C685
Q
G
P
P
A
G
S
C
Q
D
R
R
P
T
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24368
1027
118855
Y744
E
L
L
D
Q
E
I
Y
Y
F
R
K
T
V
G
Honey Bee
Apis mellifera
XP_001120586
932
107557
L649
Q
L
F
Q
E
S
K
L
I
P
L
T
N
K
F
Nematode Worm
Caenorhab. elegans
P41877
1009
116656
V726
P
R
P
K
L
P
Q
V
F
D
F
Q
F
Y
P
Sea Urchin
Strong. purpuratus
XP_001193315
953
107227
K670
G
K
K
E
K
K
K
K
R
R
D
A
K
L
D
Poplar Tree
Populus trichocarpa
XP_002307656
1206
134941
F922
S
T
E
T
S
N
I
F
S
Q
L
S
E
D
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWY3
1057
122611
R774
P
A
K
P
K
E
P
R
I
P
R
M
P
Q
L
Baker's Yeast
Sacchar. cerevisiae
P40352
1085
124509
I802
K
Q
F
L
T
N
R
I
L
T
D
P
K
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.2
83.3
N.A.
N.A.
70.1
N.A.
44.6
N.A.
N.A.
N.A.
N.A.
20
31.4
20.6
36.4
Protein Similarity:
100
99.4
97.9
89.1
N.A.
N.A.
76.4
N.A.
52.2
N.A.
N.A.
N.A.
N.A.
35.7
43.8
35.7
45.8
P-Site Identity:
100
100
100
53.3
N.A.
N.A.
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
0
0
13.3
P-Site Similarity:
100
100
100
53.3
N.A.
N.A.
33.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
20
20
6.6
26.6
Percent
Protein Identity:
29.4
N.A.
N.A.
23.5
28.4
N.A.
Protein Similarity:
44.9
N.A.
N.A.
38.2
43.9
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
40
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
8
8
0
0
0
24
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
16
16
0
0
8
16
% D
% Glu:
8
0
8
8
8
16
0
0
0
8
31
31
39
0
0
% E
% Phe:
0
0
16
0
0
0
0
8
8
8
8
0
8
0
8
% F
% Gly:
8
8
0
0
0
8
0
0
0
0
0
0
8
0
8
% G
% His:
8
0
0
0
0
24
31
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
16
8
16
0
0
0
0
0
0
% I
% Lys:
31
16
39
16
39
16
16
8
0
0
8
8
16
8
8
% K
% Leu:
0
24
8
8
8
0
0
8
8
8
16
0
0
8
39
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
16
0
0
0
0
0
0
8
0
0
% N
% Pro:
16
0
16
16
0
8
8
0
0
16
0
8
16
0
8
% P
% Gln:
16
8
0
8
8
0
8
0
8
8
0
16
0
16
0
% Q
% Arg:
8
8
0
0
0
0
8
8
8
8
24
8
0
0
0
% R
% Ser:
8
24
16
0
8
8
16
31
16
0
0
8
0
8
8
% S
% Thr:
0
8
0
31
16
0
0
8
0
8
0
8
8
39
0
% T
% Val:
0
0
0
0
8
0
0
8
31
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _